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Hosts lost as many as five wickets for 97 runs in the final session on Day 2.
Having only a single-entry visa to India, the spinner was stopped by airport authorities, causing the England squad to wait at the airport until the necessary formalities were sorted out in the afternoon.
The ECB said it will not call up a replacement and Leach will head home from Abu Dhabi.
The ECB said it will announce a replacement for Brook in due course for the series, beginning at Hyderabad from Thursday.
The left-arm bowler has played 70 one-dayers, including three matches in the ongoing World Cup, and 43 T20 Internationals since his England debut in 2015.
Topley has been ruled out of the rest of the World Cup after fracturing his left index finger in their 229-run defeat by South Africa.
The all-rounder was included in the squad for the upcoming series against New Zealand.
The exact value is unknown, but it would be worth millions of pounds each year given his earning capacity in the IPL, according to the British newspaper, The Telegraph.
The all-rounder has been added to England's Ashes squad for the first two Tests.
The proposals, which are due to be ratified by the ICC, were criticised as it will only further increase the financial disparity in the game.