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The world No. 32 Indian pair went down fighting to third seeds Rin Iwanaga and Kie Nakanishi of Japan in a 77-minute clash.
Tanisha Crasto and Ashwini Ponnappa, who had clinched the Nates International Challenge and Abu Dhabi Masters Super 100 this year, secured a win over Commonwealth Games bronze medallists Treesa Jolly and Gayatri Gopichand.
Satwiksairaj Rankireddy and Chirag Shetty defeated Singapore's Hee Yong Kai Terry and Loh Kean Hean 21-15, 21-19 in 36 minutes to also advance to the doubles quarterfinals.
In the next round, Saina will take on Malvika Bansod, who defeated Samiya Imad Farooqui 21-18 21-9.
The Indian mixed doubles pair of B Sumeeth Reddy and Ashwini Ponnappa crashed out in the opening round.
Ashwini Ponnappa lost in both the women's' doubles and mixed doubles semifinals partnering Sikki Reddy and Dhruv Kapila respectively.
Former world No. 1 Srikanth cut a sorry figure as he went down 19-21, 17-21 to France's Toma Junior Popov in a men's singles quarterfinal.
Lakshya Sen crashed out after losing to Mark Caljouw of the Netherlands 17-21, 21-16, 17-21 in the quarterfinals.
The Indian duo stunned the second-seeded Indonesian pair of Hafiz Faizal and Gloria Emanuelle Widjaja in the opening round.
Mixed doubles pair of Satwiksairaj Rankireddy and Ashwini Ponnappa produced a spirited performance before going down narrowly to top seeds Dechapol Puavaranukroh and Sapsiree Taerattanachai in the semifinals.