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After dominating the first half, it was a shocking but familiar collapse from Arsenal, whose lack of steel was the key element in the downfall of Arteta's predecessor Unai Emery.
West Ham United sacked manager Manuel Pellegrini on Saturday after a 2-1 home defeat by Leicester City.
Fourth-placed Chelsea suffered a shock 2-0 loss at home to Southampton while Harry Kane and Dele Alli were on target as Tottenham Hotspur came from behind to beat Brighton & Hove Albion 2-1.
Manchester City provided a timely reminder that they may still pose the greatest threat to Liverpool in the Premier League title race.
Chelsea's poor domestic form continued with a shock 1-0 home defeat by lowly Bournemouth, while Sheffield United moved up to fifth with a 2-0 win over fellow promoted side Aston Villa.
Liverpool took a giant step towards their first title since 1990 on Saturday when their 3-0 win at Bournemouth combined with Manchester United's 2-1 victory at Manchester City to leave the champions 14 points adrift of the Premier League leaders.
Crystal Palace claimed a first league win in six games with a 2-0 victory at Burnley and Southampton came from behind to beat fellow strugglers Watford 2-1.
Liverpool's hard-fought 2-1 win at Crystal Palace meant defending champions City went into their evening match against high-flying Chelsea 12 points behind the pacesetters.
In echoes of last season's epic Premier League title race, Liverpool and Manchester City matched each other stride for stride to eke out 2-1 victories on Saturday when both had looked set for shock defeats.
The VAR confusion was greatest at the Tottenham Hotspur stadium where the big screen flashed up that VAR had disallowed Dele Alli's equaliser in the 1-1 draw with Watford, only for the referee to signal that the goal stood.