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Liverpool now require only two more wins to guarantee lifting their first league title for 30 years.
On the evening when the European champions were expected to complete the best sequence in the history of English football's top-flight with a 19th straight league victory, they were instead hammered 3-0 by the team lying one from bottom.
The United Kingdom now has 19 confirmed cases of coronavirus and Newcastle boss Steve Bruce said the club was not taking any chances.
Goals from Chris Wood and Jay Rodriguez ensured victory for Sean Dyche's Burnley on a night when United looked nothing like a 'big six' team.
Aston Villa grabbed a priceless last-gasp victory at Watford .
With closest rivals Leicester City suffering a shock 2-1 home defeat by Southampton, Roberto Firmino's goal sent Juergen Klopp's side 16 points clear at the top with a game in hand.
Both clubs entered this season hoping to finish in the top four, but while Ole Gunnar Solskjaer has guided United to fifth place, just a point off the Champions League spots, Arsenal languish in 12th, 11 points behind fourth-placed Chelsea.
West Ham United sacked manager Manuel Pellegrini on Saturday after a 2-1 home defeat by Leicester City.
Manchester City provided a timely reminder that they may still pose the greatest threat to Liverpool in the Premier League title race.
Chelsea's poor domestic form continued with a shock 1-0 home defeat by lowly Bournemouth, while Sheffield United moved up to fifth with a 2-0 win over fellow promoted side Aston Villa.