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It was heartbreak once again in the semifinals for the Keralite as he squandered a one-game advantage to go down 21-17, 9-21, 17-21 to Angus Ng Ka Long.
This was Sen's second straight defeat at the hands of Chou in less than a month.
It was the world No 6 Zii Jia's second title on the trot after winning the Asian crown in Manila earlier this month.
Sindhu, a two-time Olympic medallist, lost 17-21, 16-21 to third seeded Chen in 43 minutes to end an impressive run in the Super 500 tournament.
The world no took just 37 minutes to get the better of Sim Yu Jin, 21-16 21-13.
Srikanth, seeded eighth in the BWF Super 500 tournament, won his first round match against Brice Leverdez of France 18-21, 21-10, 21-16 in 49 minutes.
The selection trials are scheduled here from April 15 to 20.
Sindhu suffered her fourth successive defeat to Korean youngster An Seyoung.
Prannoy suffered a 12-21, 18-21 defeat at the hands of Asian Games gold medallist and fourth seed Jonatan Christie of Indonesia.
Former top 10 player H S Prannoy also struggled past Finland's Kalle Kolionen 19-21, 21-13, 21-9 to find a place in the quarters as did former Commonwealth Games gold medallist Parupalli Kashyap.