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The Goans have qualified for the play-offs thrice and made it to the final twice, a record that testifies to their consistency in the five-year-old league.
Three-time European champions Manchester United played out a dour goalless draw away to AZ Alkmaar.
Messi returned from injury to make his second start of the season against Inter Milan in the Champions League as Barca came from behind to win 2-1 on Wednesday.
Strikes by Luis Suarez and Junior Firpo either side of halftime gave the Spanish champions their first win of the season.
It was Frankfurt's first loss in Europe in 16 games stretching back to 2006, and the win put Arsenal top of the group ahead of Standard Liege.
Salah and Mane now have 21 and 20 goals each this season -- making them the top two scorers in the Premier League.
The draw left third-placed Real an embarrassing 15 points behind runaway leaders Barcelona and six back from second-placed Atletico Madrid after 34 games.
Caparros took charge of Sevilla for the third time last month by switching role from sporting director to head coach after Pablo Machin was sacked.
Madrid are stuck in third on 57 points, 13 behind La Liga leaders Barcelona and five behind city rivals Atletico Madrid.
Lionel Messi scored his 50th career hat-trick to fire Barcelona to a 4-2 win at Sevilla on Saturday after the champions had twice fallen behind.