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Satwiksairaj Rankireddy and Chirag Shetty, who won the Korea Open, also advanced to the quarterfinals.
This was the double Olympic medallist's seventh first-round exit in 13 BWF World Tour events in 2023.
Lakshya, who enjoyed an 5-2 win-loss record against Feng coming into the match, had defeated the Chinese 21-18, 22-20 to win the Canada Open.
Lakshya will face second seed Li Shi Feng of China in the semifinals.
Sindhu will face China's Gao Fang Jie next, while it will be an all-Indian clash in the men's singles with third seed Sen taking on 19-year-old Sankar.
B Sai Praneeth lost to 23-year-old world No. 7 Li Shi Feng of China after a gruelling match.
After an impressive start, Sen maintained the lead throughout to eventually win by 21-18.
Sen has a 4-2 head-to-head record against his final opponent Li Shi Feng, the reigning All-England champion.
Sindhu, a double Olympic medallist, stamped her authority over Fang Jie to register her first victory in four meetings against her opponent with a dominating 21-13 21-7 margin in the women's singles quarterfinals late on Friday night.
Sindhu advanced after her opponent Natsuki Nidaira of Japan gave a her a walkover. Sen notched up a 21-15, 21-11 win over Brazil's Ygor Coelho in 31 minutes.