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The 31-year-old Salah, who has 151 Premier League goals for Liverpool, changed his boots at halftime and the switch paid off handsomely.
The 37-year-old Lloris, whose contract with Spurs was due to expire in June, has signed a one-year deal with an option to extend for 2025 and 2026 after an 11-year stay in London.
Rodri and Julian Alvarez scored in the 2-0 home win for Pep Guardiola's side.
Second-placed Arsenal remain on 40 points, two behind Liverpool who beat Burnley 2-0 on Tuesday.
Pep Guardiola's newly-crowned FIFA World Club champions had lost ground in the title race after a run of one win in six league games.
Manchester City slipped out of the top four as Tottenham Hotspur made up ground with a third consecutive victory, beating Everton 2-1 at home.
Manchester United were one of the first to say they remain committed to playing in competitions run by Europe's soccer governing body UEFA, as did German champions Bayern Munich.
Diogo Dalot was sent off in stoppage time for two yellow cards -- both for dissent.
Arsenal's second league defeat of the season leaves Mikel Arteta's men one point behind Liverpool, who went top with a controversial 2-1 win at Crystal Palace earlier on Saturday.
Leon Bailey's deflected strike after a surging run in the 74th minute sealed Villa's club record-equalling 14th successive home league win as they moved above City into third place.