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Juventus, with 80 points, are eight clear of Inter Milan with four games each to play followed by Atalanta on 71 and Lazio fourth on 69.
Having taken two points from their last three games, Juventus are on 77 points, seven ahead of Atalanta, who thumped Brescia 6-2 on Tuesday, with five matches remaining.
The win left Juventus with 75 points from 30 games, seven ahead of second-placed Lazio who suffered a 3-0 loss to AC Milan at home.
Juventus, with 66 points from 27 games and chasing a ninth successive title, extended their lead to four points over Lazio, who visit Atalanta on Wednesday.
Juve qualified for Wednesday's final on away goals following their 1-1 draw in the first leg of the semifinal, played on February 13, and face Napoli or Inter Milan.
Long-standing defender Giorgio Chiellini led the players' negotiations amid reports in the Italian media that Ronaldo had agreed to sacrifice 3.8 million euros of his yearly wage to ease the financial burden on the club while Italy is in lockdown.
Midfielder Lucas Tousart scored the only goal in the opening half to give Lyon, who are bidding to reach the quarter-finals for the first time since 2010, a deserved win.
The Turin side, with 13 points from five games, made sure of winning Group D with one match to spare.
Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.