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Seferovic put Switzerland ahead 57 seconds into the clash at Stade de Geneve with a close-range header after defender Silvan Widmer set him up with a precise cross inside the area.
Wales held Belgium to a 1-1 draw to claim their first point after Brennan Johnson scored a late equaliser to cancel out a Youri Tielemans goal in Cardiff.
Mbappe, who came on as a substitute after the break, found the back of the net with a shot into the top corner seven minutes from time to cancel out Andreas Weimann's first-half opener.
An early goal from Pablo Sarabia earned Spain a 1-0 win in Switzerland, their first victory of this year's competition.
Swiss prosecutors accuse the two men, once among football's most powerful figures, of illegally arranging the 2 million Swiss franc ($2.04 million) payment in 2011. Blatter and Platini both deny the charges.
The defending champions went ahead through Adrien Rabiot's goal early in the second half but Andrej Kramaric's late penalty gave the hosts a deserved draw.
Sepp Blatter and Michel Platini each face up to five years in prison, but suspended sentences are a likely option.
Switzerland are on zero after back-to-back losses and are now winless in their last four encounters since they qualified for the World Cup in Qatar.
Denmark came from behind to defeat France 2-1 in their Group A1 clash at the Stade de France.
Ronaldo, his country's record goal-scorer, came on in the 62nd minute but failed to find the net as a late Ricardo Horta strike salvaged a 1-1 draw for Portugal against Spain in the Nations League.