Shock US Open exit for Novak Djokovic in first round

Novak Djokovic made his earliest exit at a Grand Slam in more than two decades as the Serb succumbed to injury and illness in a shock first-round defeat by unseeded Argentine Mariano Navone at the US Open.

The 39-year-old had arrived at Flushing Meadows with the aim of winning a fifth title and a record 25th major crown overall but crashed out 7-6(5) 5-7 4-6 6-2 6-1 to send shockwaves through the final Grand Slam of the year.

Former champion Daniil Medvedev and highest-ranked American Jessica Pegula advanced with little fuss earlier in the day, as players began their campaigns to grab a slice of the record prize purse of $108 million up for grabs.

A bit shaken
The last time Djokovic lost in the first round of a Grand Slam was at the Australian Open in 2006 and the Serb did not go down without a fight despite battling shoulder and back problems and vomiting midway through the match.

"I pretty much despised every moment I spent on the court for that," Djokovic told reporters.

With world number one Jannik Sinner absent and defending champion Carlos Alcaraz returning after a lengthy spell out injured, Djokovic looked primed for a run at a record 25th Grand Slam.

But Navone had not read the script and completed the biggest win of his career against his idol at Arthur Ashe Stadium. "I was 0-3 down, feeling a bit nervous out of respect for the star I was up against," the world number 49 told ESPN.

"It's tough to play against Novak, he's an idol. He never looked particularly comfortable with his shots or physically, that's the truth," he added. "In the fifth set he was a bit shaken. I had to focus on my game. You don't get many chances to play an idol on a stage like this ... it's incredible what I'm feeling; it's all so exciting. It's mad."