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Alcaraz defeated a drained Alexander Zverev 6-3 6-2 6-4 on Wednesday.
On another steamy hot day with temperatures in the mid-90s Fahrenheit (32 Celsius) Medvedev was better able deal with the stifling humidity and heat inside Arthur Ashe Stadium than eighth seed Rublev to make the Flushing Meadows semi-finals for the fourth time in five years.
Sabalenka faces China's Zheng, who knocked out 2022 finalist Ons Jabeur, in the qusarterfinals.
Bopanna and Ebden, who are seeded sixth, brushed aside the Australian duo in less than an hour.
The Greek earned his 10th career crown and extended his perfect ATP head-to-head record against de Minaur to 10-0.
The Serb won the quarterfinals, 4-6 6-1 6-4 6-3, to stay on track for his fifth straight title.
Djokovic defeated Poland's Hubert Hurkacz 7-6(6) 7-6(6) 5-7 6-4.
The American defeated Ukraine's Lesia Tsurenko 6-1, 6-3 in the fourth round.
Friday's draw at the All England Club pitched women's top seed Iga Swiatek against China's 33rd-ranked Zhu Lin, a potentially tricky first hurdle for the Pole.
Top-ranked Carlos Alcaraz was imperious against Denis Shapovalov in the night session, blasting past the Canadian 6-1, 6-4, 6-2 to book a meeting with Lorenzo Musetti.