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The Romanian will not play at Roland Garros this year because she is recovering from a calf injury.
World No. 1s Ash Barty and eight-time champion Novak Djokovic will lead the fields at the Grand Slam slated to be held from February 8-21.
Brady produced a fearless brand of tennis to down 2016 champion Kerber 6-1, 6-4.
The 32-year-old has not won a title since picking up her third Grand Slam at Wimbledon in 2018 under then coach Wim Fissette.
The unseeded former world No. 1 won 6-3, 6-3 on Rod Laver Arena and faces 30th seed Anastasia Pavlyuchenkova of Russia in the last eight.
The organisers said they are in active discussions with the Women's Tennis Association, the women's tour governing body, to identify an alternate week for hosting the event.
The list of the world's top 15 female athletes is topped by Serena Williams, with total earnings of $29.2 million. On the second spot is Naomi Osaka.
The result denied Serena Williams from equalling Margaret Court's all-time record of winning 24 Grand Slam singles titles.
Kerber's second-round exit is her worst Wimbledon result since 2013 and follows a first-round exit at the French Open in May.
Kerber began her title defence by surviving a battle of wits at Wimbledon as she beat fellow German Tatjana Maria on Centre Court.