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Khawaja, who has scored a match-saving 141 in the first Test, is now a doubt for the start of the home series against India, which begins in Adelaide on December 6.
By the close on the third day, Pakistan had Shaun Marsh dismissed for four - bowled by left-arm paceman Mir Hamza for his first Test wicket.
The incident happened in the 52nd over when Australian pacer Peter Siddle got Ali to edge a delivery to third-man.
The tourists were left on 20-2 after seven overs going into the second day.
Pakistan will need seven more wickets while Australia require another 326 runs for an improbable victory to take a 1-0 lead in the two-match series.
Australia openers Usman Khawaja and Aaron Finch had launched a strong reply to Pakistan's first innings total of 482.
Australia trail Pakistan by 452 runs with all ten wickets intact.
Irshad was accompanied by key witnesses in the case who were to appear in the court to give their statement.
The ministers and the advisors of the Pakistan Tehreek-e-Insaf government said the agreement "unfairly benefits Chinese companies," the paper reported.
China and Pakistan pledged to push forward the all-weather strategic cooperative partnership between them to a new high.