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Manchester United moved into the top four of the Premier League with a last second goal from Marcus Rashford earning them a 1-0 win over West Ham United at Old Trafford.
An 82nd minute strike from Joao Moutinho earned Wolves their first win at Old Trafford since 1980 and moved Bruno Lage's side up to eighth place.
The result stretched Manchester United interim manager Ralf Rangnick's unbeaten start to four games in all competitions.
United came into the contest on the back of a 5-0 hammering by their bitter rivals Liverpool but goals from Ronaldo, Edinson Cavani and Marcus Rashford sealed a comfortable win.
On the night he set the new record for the most appearances in the competition, the 36-year-old delivered the killer blow to save his manager Ole Gunnar Solskjaer from another disappointing result.
The Belgium international is in line to feature against Arsenal in the Premier League on Sunday.
The result ensures that with one round of group games still to play, Paraguay qualify from Group A along with Chile, Argentina and Uruguay.
The result in a game that was end-to-end but lacking in real excitement at a cavernously empty stadium in Brasilia leaves Uruguay joint bottom of Group A with no points.
Villarreal goalkeeper Geronimo Rulli kept his composure to score in a nerve-shredding, seemingly never-ending shootout then denied David de Gea as his side won their first major trophy by beating Manchester United 11-10 on penalties.
United's win put on hold the title celebrations of champions-elect Manchester City.