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Venezuelan-born Muguruza won the French Open in 2016 and Wimbledon in 2017, and she reached the final of the Australian Open in 2020.
Krejcikova will climb from No. 30 to 16 on Monday after beating the top-ranked Iga Swiatek 6-4, 6-2 in Saturday's Dubai final.
World No. 1 Iga Swiatek was made to work by American Lauren Davis before sealing a 6-3, 6-4 win to reach the fourth round at New York for the second straight year.
The US Open draw did Serena no favours, the 40-year-old American landing in the bottom quarter where fifth-seeded Tunisian Ons Jabeur, the Wimbledon runner-up, 10th-seeded Daria Kasatkina and last year's losing finalist Leylah Fernandez all lurk.
The first stop on Serena Williams' farewell tour came to a quick end as she fell 6-2 6-4 to Belinda Bencic in second-round action at the Canadian Open.
At age 22, Puig became Puerto Rico's first Olympic gold medallist with a stunning performance.
The 21-year- became the first high-profile woman player to opt out of the Australian Open -- the opening major of 2022 -- due to mental health issues arising from "quarantining".
Muguruza defeated Anett Kontaveit 6-3, 7-5 to become the first Spaniard to win the WTA Finals title.
In their first career meeting, Muguruza's superior firepower put Badosa on the back foot from the outset.
The in-form Greek will meet red-hot Estonian Anett Kontaveit in the semifinals.