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Champions Liverpool missed an opportunity to go clear at the top of the Premier League as they needed a late Salah penalty to earn a 1-1 draw at lowly Fulham.
The results leave Tottenham Hotspur top of the table on 24 points level with Liverpool.
Harry Kane scored his 250th career goal for club and country after laying on Son Heung-min's 10th league goal of the season as Tottenham beat Arsenal 2-0 to reach 24 points from 11 games.
Defending champions Liverpool still moved a point clear at the top of the table with 21 points from 10 games while Tottenham, who play at Chelsea on Sunday, have 20 points from nine.
Holders Bayern Munich and Manchester City booked their places in knockout phase, while Atalanta stunned Liverpool.
Liverpool stumbled in their bid to reclaim the top spot with a 1-1- draw at Manchester City.
The result left Real, winners of a record 13 titles in Europe's premier club competition, level on four points with Shakhtar Donetsk, one point behind leaders Borussia Moenchengladbach and two ahead of bottom placed Inter.
Chelsea cruised to a 3-0 scoreline at winless Burnley while City edged Sheffield United 1-0 away with full-back Kyle Walker scoring against his former club.
A late equaliser from Jannik Vestergaard earned Southampton a 3-3 draw away to Chelsea.
Everton remained top of the table on 13 points, three ahead of Liverpool, after an incident-packed end to the 237th Merseyside derby.