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Arsenal posted a 3-1 win over 10-man Tottenham at the Emirates Stadium.
Arsenal defeated Brentford 3-0 to return to the top of the points table.
Newcastle United's record signing Alexander Isak scored on his debut to put his side ahead at Anfield but Liverpool snatched a 2-1 victory deep in stoppage time through Fabio Carvalho.
League leaders Arsenal scored late to beat Fulham 2-1 in the premier league.
The Arsenal captain scored twice in a solid 3-0 win to move to top of the table.
Gabriel Martinelli scored the first goal before home defender Marc Guehi turned the ball into his own net late on at Selhurst Park.
The Big Six in have all been busy with many high profile exits and entries on the horizon.
British media reported the 25-year-old Brazil international was signed in a deal worth 45 million pounds.
Thanks to their superior goal difference, Spurs will only need a point at already-relegated bottom side Norwich City on Sunday to qualify for Europe's elite competition.
Arteta took over from Unai Emery in December, 2019, and his previous deal was set to expire at the end of next season.