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Arsenal struggled from the start to find any rhythm, with Palace very much the better side in the opening period.
Everton's plummet towards the relegation zone continued as they lost 1-0 at home to Wolverhampton Wanderers but Leeds United gained some respite with a last-gasp 2-1 win over bottom club Norwich City.
Arsenal's third successive league win lifted them above West Ham United into fifth place with 45 points, one behind Manchester United but having played two fewer games.
City extended their lead over Chelsea, who take on third-placed Liverpool on Sunday, to 11 points, while Arsenal are fourth on 35 points.
A Cristiano Ronaldo penalty in the 75th minute helped Manchester United to an unconvincing 1-0 win at bottom team Norwich City and lifted them to fifth.
Spartak Moscow won 1-0 at Legia Warsaw to secure an automatic last-16 berth.
Manchester United suffered a fourth defeat in five Premier League games as they went down 4-1 at Watford to pile more pressure on manager Ole Gunnar Solskjaer.
A second-half goal from Emile Smith-Rowe gave them a 1-0 home win over Watford.
Goals from Karim Benzema and Kylian Mbappe earned them a 2-1 win over Spain at the San Siro.
Italy, trailing by two goals at the break, had to play the entire second half with 10 men after captain Leonardo Bonucci was sent off.