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The Dutchman, who wrapped up the title last month in Japan with four races to spare, was unchallenged as he led from pole position to chequered flag.
There are many reasons why Brazil will not be taking the Swiss team lightly.
The inaugural World Cup winners have gone for a mix of youth and experience.
If Spain and Germany justify their billing, it won’t be difficult for them to progress from the group.
Max Verstappen led from pole position at the Autodromo Hermanos Rodriguez, taking the chequered flag 15.186 seconds clear of Mercedes's Lewis Hamilton.
Marcelo Martinez is hoping Messi will lift the trophy at his fifth and final World Cup.
The title, clinched with three races to spare, ended an eight-year streak by Mercedes who have yet to win a race this season.
A recovery tractor was on the track while the AlphaTauri driver was still lapping at speed in heavy rain and spray.
The Dutchman's closest rival Charles Leclerc was handed a five-second post-race penalty in the Japanese GP.
Real Madrid are level with rivals Barcelona on 19 points at the top of standings, with Barca ahead on goal difference.