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The sixth-seeded Indo-Australian pair defeated the American duo of Nathaniel Lammons and Jackson Withrow in the quarterfinals.
Coco Gauff won the final 10 games of her match against Elise Mertens, completing a 3-6, 6-3, 6-0 comeback
The British charge at the US Open will carry on without 2012 champion Andy Murray, who was outclassed by Bulgarian Grigor Dimitrov.
Bopanna and Ebden, who are seeded sixth, brushed aside the Australian duo in less than an hour.
The top-ranked Americans were hardly tested as ninth seed Fritz crushed compatriot Steve Johnson 6-2 6-1 6-2 in Louis Armstrong Stadium after Tiafoe, the 10th seed, beat American Learner Tien 6-2 7-5 6-1 inside Arthur Ashe Stadium
Badosa posted on social media that the injury has forced her to shut down her season.
The win was Djokovic's 95th career title and 39th Masters 1000 crown.
Samsonova had to play the match about two hours after upsetting third seed Elena Rybakina in a rain-postponed semifinal clash meant to be played on Saturday.
Germany's Jan-Lennard Struff has also withdrawn from the final Grand Slam of the year.
Play in the quarterfinal clash between world No. 7 Gauff and Swiss Belinda Bencic was stopped briefly when a fan in the stadium was in distress but paramedical staff stepped in to address the issue and the match resumed.