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Argentina failed to score for the first time since June, 2019.
Everton Ribeiro got his second goal in two games to help Brazil on their way to a 2-0 win over Peru in another World Cup qualifier.
The result means that Argentina will face Ecuador in the last eight on Saturday while Uruguay, who beat Paraguay 1-0, will play Colombia the same day.
The draw at an empty stadium in central Brazil marked the first time Brazil have not picked up a win since they lost 1-0 to Argentina in a friendly in November 2019.
The result ensures that with one round of group games still to play, Paraguay qualify from Group A along with Chile, Argentina and Uruguay.
Previous studies of ivermectin, which show that early administration with ivermectin can reduce viral load and the duration of symptoms in some patients with mild Covid.
The victory in Brasilia was Argentina's second 1-0 win in a row in this tournament and their 16th match without defeat since losing in the Copa America semi-final in 2019.
The result in a game that was end-to-end but lacking in real excitement at a cavernously empty stadium in Brasilia leaves Uruguay joint bottom of Group A with no points.
It took over a year for the COVID-19 death toll to hit 2 million, while the next 2 million were recorded in just 166 days.
Paraguay went behind to an early penalty but scored three times in the second half for a 3-1 win over Bolivia.