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Angel Di Maria took over as captain in Messi's absence and shone, providing two assists before halftime
In other qualifiers, Paraguay drew 0-0 with Peru while Colombia claimed a 1-0 home win over Venezuela.
City's striker and Spain's World Cup winner won the prizes at a ceremony in Monaco.
Messi extended his winning streak since joining the MLS side to seven games.
Inter Miami crushed Philadelphia Union 4-1 to set up a title clash with Nashville SC.
Saudi Professional League (SPL) club Al-Hilal announced that Neymar had signed a deal until 2025.
There was no immediate comment from the Ligue 1 champions, owned by Qatar Sports Investments, but French newspaper L'Equipe said the deal could net 31-year-old Neymar 160 million euros ($175 million).
PSG opened their Ligue 1 title defence with a goalless draw at home against Lorient on Saturday as the team's prize asset watched from the stands.
Inter Miami will meet Philadelphia away on Tuesday (Wednesday 4.30 am IST) for a place in the final.
Kohli rubbished reports suggesting that he rakes in a staggering sum of Rs 11.45 crore from every post of his on Instagram.