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The Spaniard is chasing a second Grand Slam title after winning the US Open crown last year, while the Serbian veteran is on course for a record-breaking 23rd men's singles major.
Novak Djokovic overcame a first-set blip to beat Russian Karen Khachanov 4-6 7-6(0) 6-2 6-4 and reach the French Open semi-finals, staying on course for a record-breaking 23rd men's singles Grand Slam title.
The Serbian World number three has 22 Grand Slam titles.
Top-ranked Carlos Alcaraz was imperious against Denis Shapovalov in the night session, blasting past the Canadian 6-1, 6-4, 6-2 to book a meeting with Lorenzo Musetti.
World number two Medvedev was tipped as a surprise contender for the Paris title following his Rome triumph, but the Russian was blown away by Wild in gusty conditions on Court Philippe Chatrier and crashed to a 7-6(5) 6-7(6) 2-6 6-3 6-4 defeat.
Sloane Stephens, runner-up at Roland Garros in 2018, dismantled former world No. 1 Karolina Pliskova 6-0, 6-4.
Argentia named World Team of the year after their triumph at the 2022 World Cup in Qatar.
The victory was the fourth ATP Masters 1000 trophy for Alcaraz.
Djokovic, one of the most high-profile athletes unvaccinated against COVID-19, missed the US Open in 2022 due to his vaccine status.
The US currently bars unvaccinated foreigners from entry into the country, a policy that is expected to be lifted when the government ends its COVID-19 emergency declarations on May 11.