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Rublev, ranked fifth in the world, began to despair after losing the first set and failed to put up much of a fight in the second.
Jannik Sinner made a dream start in front of his home crowd with a 6-4, 6-4 defeat of Stefanos Tsitsipas in their opening Green Group clash.
World number 128 Stricker used a massive serve, booming forehand and solid net play during a gruelling four-hour encounter in which he broke the Australian Open finalist six times for his first top-10 win
The Greek earned his 10th career crown and extended his perfect ATP head-to-head record against de Minaur to 10-0.
Djokovic defeated Poland's Hubert Hurkacz 7-6(6) 7-6(6) 5-7 6-4.
Equalling his best ever showing at Wimbledon, Daniil Medvedev downed Hungary's Marton Fucsovics 4-6 6-3 6-4 6-4 to reach the fourth round.
The Tunisian won 6-1, 6-2 to storm into the third round.
Friday's draw at the All England Club pitched women's top seed Iga Swiatek against China's 33rd-ranked Zhu Lin, a potentially tricky first hurdle for the Pole.
The Spaniard is chasing a second Grand Slam title after winning the US Open crown last year, while the Serbian veteran is on course for a record-breaking 23rd men's singles major.
Novak Djokovic overcame a first-set blip to beat Russian Karen Khachanov 4-6 7-6(0) 6-2 6-4 and reach the French Open semi-finals, staying on course for a record-breaking 23rd men's singles Grand Slam title.