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Malik was previously married to Indian tennis star Sania Mirza, with whom he has a son.
The Indo-Romanian combo went down 3-6, 3-6 to their 10th-seeded opponents at the Rod Laver Arena.
While Shang fell short in his bid to become the first Chinese man to reach the fourth round of a Grand Slam in the Open era, the country will have a women's singles player in the second week as 12th seed Zheng.
Japan is the fifth nation to pull off a fiendishly tricky 'soft landing' after the United States, the Soviet Union, China and India.
Russian teenager Mirra Andreeva produced a thrilling comeback from 5-1 down in the third set to beat Frenchwoman Diane Parry 1-6, 6-1, 7-6(5).
Sriram Balaji,entered the second round of the men's doubles in the company of his Romanian partner Victor Cornea.
Four-time Grand Slam champion Swiatek has an excellent record against lower-ranked players but really had to dig deep into her reserves to overcome Collins in a dramatic but scrappy three-hour contest on Rod Laver Arena.
Nagal began in the same dominating fashion but the 18-year-old wild card entrant got better as the game progressed to walk out a winner.
Fourth seeds Coco Gauff and Jannik Sinner, along with home hope Alex de Minaur and world number 11 Barbora Krejcikova progressed.
Nagal's win on Tuesday was the first time in 35 years that an Indian beat a seeded player in a Grand Slam.