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Deschamps surprisingly omitted Lucas Digne and Ferland Mendy, leaving the squad short of left-backs, while AC Milan keeper Mike Maignan was left out because of a leg muscle injury.
The FIFA World Cup is the biggest test for a footballer and greatness is attained based on the heroics in the showpiece.
France salvaged their place in the top tier at the end of a dismal campaign.
Victory means Real return to the top of the LaLiga table on 18 points from six games, two ahead of Barcelona in second.
Denmark beat Austria 2-0 to stay top on nine points and cannot be caught by France, who are in danger of being relegated, with two games left in the group.
Mbappe, who came on as a substitute after the break, found the back of the net with a shot into the top corner seven minutes from time to cancel out Andreas Weimann's first-half opener.
United are left to focus on a Premier League campaign where they face a real battle to make the top four and earn a place in next year's Champions League.
Atletico had many opportunities to extend their lead and hit the post twice but were punished by a defensive mistake which gifted the ball to Bruno Fernandes 10 minutes from time.
Atletico won 3-1 at Porto in a tense, ill-tempered game as both sides finished with 10 men.
Holders France ran riot to reach the finals with a match to spare after four goals from Kylian Mbappe helped them to an 8-0 home demolition of Kazakhstan.