Roberto Firmino scored twice and Marquinhos and Philippe Coutinho also got goals as Brazil hammered Bolivia 5-0 in their opening World Cup qualifier in Sao Paulo on Friday.
Brazil had never lost a World Cup qualifier at home, a run that stood at 54 matches going into Friday's game, and they never looked in danger of losing that record.
Marquinhos put the home side 1-0 up with a header after 16 minutes before Firmino scored after 18 and 49 minutes, both times by getting on the end of low crosses into the penalty box.
Brazil were rampant down the flanks and the Bolivian defence had little answer to the crosses of Renan Lodi and Everton and the dangerous midfield promptings of Neymar, who was unlucky not to get his name on the scoresheet.
The fourth came after 66 minutes, when a glancing touch from Rodrygo deflected off defender Jose Maria Carrascos shoulder and Philippe Coutinho completed the rout with a header seven minutes later.
Bolivia, who last qualified for the World Cup finals in 1994, started with an inexperienced side under a torrential rain at Corinthians' Neo Quimica Arena and had just one shot on target compared to Brazil's 10.
The top four teams in the 10-team South American group qualify directly for Qatar 2022 and the fifth-placed side goes into an inter-regional play-off.
Brazil now travel to Lima to face Peru on Tuesday, while Bolivia are at home the same day to Argentina, who opened their campaign with a 1-0 win over Ecuador on Thursday.
Colombia sink Venezuela
Colombia scored three goals in a superb first half to beat Venezuela 3-0 and get their 2022 World Cup qualifying campaign off to an impressive start at home in Barranquilla.
Venezuela are the only side in South America never to have reached the World Cup finals and they showed why in a disastrous opening 45 minutes at a fan-free stadium on Colombias coast.Duvan Zapata put the home side 1-0 up after 16 minutes when he slid in and finished off a delicious low cross from Juan Cuadrado.
His Atalanta teammate Luis Muriel made it two nine minutes later when he scored with a first-time shot from 10 meters out. Muriel then got Colombia's third just seconds before the half-time whistle, when he completed a rapid counterattack.