New York: The research project about traumatic brain injuries, headed by a Keralite, has provided a significant breakthrough in neuropathology. The findings of the research done by Dr Abdul Muneer, PhD, Associate Professor of Neuroscience at the John F Kennedy University Medical Center at Edison, New Jersey and his team have been published in the medical journal eNeuro.
The discovery shows that post traumatic brain injury could initiate nueroinflammatory responses and cause cognitive and sensory motor deficits. Intercellular adhesion molecule – 1 (ICAM – 1) promotes inflammation and transmigration of circulating leukocytes across the blood – brain barrier. Traumatic brain injury causes the cells to express ICAM – 1 and release cytokines which then leads to neuroinflammation and neurodegeneration.
The team that had begun their research in 2017 had used in - vitro human brain microvascular endothelial cells and ICAM -1 knockout mouse for the study. Dr Muneer, a native of Mangalpady in Kasargod said that the latest research would be helpful while treating traumatic brain injuries in the future.