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Shelton showed he could be a threat over the next two weeks as he broke Thiem again to close out the second set.
The last time Djokovic played all four majors in a season without winning one was 14 years ago.
Djokovic, who has not competed since winning the gold medal at the Paris Olympics, will begin against a qualifier and is expected to meet Andrey Rublev in the quarterfinals and fourth seed Alexander Zverev in the semis.
Both players are recovering from injuries that kept them out of the Paris Olympics.
The two-time Grand Slam champion said she has never used any banned substances, and that Quantum's negligence and false claims that its supplement was legal has harmed her career and caused humiliation.
Nagal's win on Tuesday was the first time in 35 years that an Indian beat a seeded player in a Grand Slam.
The win by the cool and collected Swiatek sets up a final showdown with American Jessica Pegula, and she can end the year on top if she is able to hoist the trophy
The 31-year-old former Wimbledon and French Open champion had been provisionally suspended since October 2022 after testing positive for banned blood-booster roxadustat at the US Open last year
Djokovic said he received advice on his own career from Bryant, who died in 2020 in a helicopter crash that also killed his daughter, Gianna, and seven others.
The Serbian is the first man to win three Grand Slam events in the same season four times.
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