The world No. 9 Indian pair lost 16-21, 20-22 to the top seeds Marcus and Kevin of Indonesia.
The Indian duo upset the world No. 3 pair of Li Jun Hui and Liu Yu Chen in the quarterfinals.
Both B Sai Praneeth and Parupalli Kashyap bowed out of the competition after losing their respective second-round matches.
Saina Nehwal's poor run of form continued as the Olympic bronze-medallist lost to local favourite Cai Yan Yan in straight games.
World No.6 Sindhu, who made early exits in China, Korea and Denmark, lost 13-21 21-18 19-21 to world No.42 Pai in a 74-minute women's singles match.
Almost a month after dispatching Ginting en route to his World Championships bronze at Basel, world No. 15 Praneeth went down to the 21-16, 6-21, 16-21 in 55 minutes to end his campaign.
Doubles specialist Satwiksairaj Rankireddy also had a dismal day as he suffered twin defeats, losing both the men's doubles and mixed doubles pre-quarterfinals.
India's top shuttler Sindhu beat Xuerui 21-18, 21-12 in just 34 minutes to seal a place in the pre-quarterfinals.
World No. 26 Satwik and Ashwini showed their grit as they recovered from a mid-game slump to outwit sixth seeds Praveen Jordan and Melati Daeva Oktavianti 22-20, 17-21, 21-17.
American great Serena Williams was left out of the China Open tennis draw on Friday as reports said she has called time on her season following her meltdown at the US Open.