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Son Heung-min struck a stoppage-time winner after a dreadful error from Bjorn Engels as Tottenham Hotspur won 3-2 at Aston Villa to move up to fifth in the Premier League.
United are three points behind fourth-placed Chelsea and one ahead of Tottenham Hotspur while struggling Watford stayed 19th on 24 points.
The season will get back under way with Aston Villa taking on Sheffield United and Manchester City clashing with Arsenal, which are both games in hand.
Thirteen months on from the match that finally drew the curtain on Jose Mourinho's time in charge of Manchester United, the Red Devils again find themselves living in Liverpool's shadow ahead of their return to Anfield on Sunday.
Goals from Chris Wood and Jay Rodriguez ensured victory for Sean Dyche's Burnley on a night when United looked nothing like a 'big six' team.
Liverpool's grip on the title race tightened and while Klopp was not about to echo the euphoric sentiments of the club's jubilant fans, he was upbeat about his team's display.
Aston Villa grabbed a priceless last-gasp victory at Watford .
With closest rivals Leicester City suffering a shock 2-1 home defeat by Southampton, Roberto Firmino's goal sent Juergen Klopp's side 16 points clear at the top with a game in hand.
Oli McBurnie's goal earned Sheffield United a 1-0 home win over West Ham United but they needed a stoppage-time VAR intervention to secure the points.
The Argentine striker struck the third, fifth and sixth goals as City ran riot at Villa Park, taking his league tally to 177
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