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The 18-year-old became the first ever qualifier to win a Grand Slam title and the first British woman to hoist a major trophy since Virginia Wade triumphed at Wimbledon in 1977.
Briton Emma Raducanu became the first qualifier to reach the US Open final by beating Greece's Maria Sakkari 6-1, 6-4.
Sakkari leveraged her powerful serve and excellent court coverage to overpower Pliskova and dedicated her win to the people of Greece, who have endured a summer of brutal wildfires.
Emma Raducanu overwhelmed American Shelby Rogers 6-2, 6-1 to reach her first Grand Slam quarterfinal.
Results 21-24