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Lakshya, ranked world No. 21, prevailed in a seesaw battle to notch up a 21-18, 12-21, 21-19 win over three-time junior world champion Vitidsarn.
Former champion Lakshya went down to Singapore's Loh Kean Yew 18-21, 12-21, while Srikanth was edged out by Malaysian Lee Zii Jia 21-19, 22-20.
Sourabh Verma crashed out of the Super 500 tournament.
Sen scored a 21-17, 21-15 victory to set up a clash with Kunlavut Vitidsarn of Thailand.
Srikanth showed great determination to outwit NG Ka Long Angus in a hard-fought match.
Kashyap and Srikanth went down fighting in the opening round.
Only Satwiksairaj Rankireddy and Chirag Shetty could manage a win in the tie as they beat He Ji Ting and Zhou Hao Dong 21-14 21-14.
The Singapore Open, a Super 500 event on the BWF World Tour, was the last tournament offering Race To Tokyo ranking points inside the Olympic qualifying window.
Saina and Srikanth's qualification for the Tokyo Games hinged on the Kuala Lumpur event followed by the Singapore Open (June 1-6).
The former national coach added it will be very tough for Saina Nehwal to make it to Tokyo given her recent results.
Results 51-60 of 123
