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Manish Pandey has stepped in to lead Sunrisers Hyderabad as Kane Williamson has a minor injury.
Mumbai were bowled out for 111 in 18.1 overs, losing 10 wickets for 54 runs after being 57/0 at one stage.
This means that the afternoon match between Sunrisers Hyderabad and Mumbai Indians in Abu Dhabi on October 8 will be shifted to the evening slot.
Nathan Coulter-Nile replaces Adam Milne in the Mumbai Indians side while Mayank Agarwal misses out for Punjab with stiff neck.
Fans, albeit a limited number, will also be present at an IPL venue for the first time since 2019.
The big win lifted KKR to fourth place with eight points from nine matches, while Mumbai slipped to sixth.
Mumbai head coach Jayawardene said Indian all-rounder Hardik Pandya was also rested for the game against Chennai due to a minor injury.
Gaikwad batted through the innings to lift CSK from a precarious 7/3 to 156/6.
The rookie opener smashed 53 off 33 balls as KKR outplayed defending champions Mumbai Indians by seven wickets.
There has been a lot of speculation about Pandya's fitness, especially since the ICC T20 World Cup is around the corner.
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