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The match will be held on September 28 at Greenfield Stadium in Thiruvananthapuram. India have a 1-1 record in T20Is here.
'You can't just fill us up and we'll go out there and be ready to be fuelled up again,' said the England all-rounder who quit ODIs after the first match against South Africa on Tuesday.
South Africa secured a 62-run victory in sweltering heat in the first One-Day International.
Police say they are investigating reports that a group of men arrived in a minibus taxi and opened fire on some of the patrons at the bar late Saturday night.
While Gaikwad's showing was patchy against South Africa, he played a match-turning innings of 57 (35 balls) in the third game at Visakhapatnam, which started India's comeback after being down 0-2.
The touring side won the first two matches before India bounced back to level the series at 2-2.
India levelled the five-match series 2-2 after the visitors lost the fourth T20I by 82 runs.
Harshal Patel (4/25) and Yuzvendra Chahal bagged (3/20) helped India make it 2-1 in five-match series.
Klaasen scored 81 off 46 deliveries to help the visitors post a 4-wicket win.
The all-rounder returned to the Indian team after leading Gujarat Titans to IPL 2022 title.