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The Serb was back roaring into the skies in triumph as he captured a 13th Grand Slam title to end a 25-month barren run at the Slams.
The Swiss eight-time champion and top seed was beaten 2-6, 6-7(5), 7-5, 6-4, 13-11 by eighth-seeded Anderson before a stunned crowd.
History books will show that Anderson came out on top in a 7-6(6), 6-7(5), 6-7(9), 6-4, 26-24 epic that lasted six hours and 36 minutes .
The 37-year-old shrugged off the passing of time to swagger past the dangerous Anderson 6-4, 6-3 and reach the semi-finals.
The world number one was immaculate from start to finish against the 32-year-old as he put himself within touching distance of a record-equalling sixth title at the year-ender.
Wimbledon finalist Anderson took a medical time-out mid-way through the four-set match before becoming the highest ranked player to be ousted from the first major of the year.
The victory confirms the 20-year-old as a member of tennis' new generation of men's players who can challenge the game's long-dominant players.
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