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He will be replaced in the draw by Zizou Bergs.
World number 128 Stricker used a massive serve, booming forehand and solid net play during a gruelling four-hour encounter in which he broke the Australian Open finalist six times for his first top-10 win
The Greek earned his 10th career crown and extended his perfect ATP head-to-head record against de Minaur to 10-0.
The Tunisian won 6-1, 6-2 to storm into the third round.
The Spaniard is chasing a second Grand Slam title after winning the US Open crown last year, while the Serbian veteran is on course for a record-breaking 23rd men's singles major.
The Serb also equalled Rafael Nadal's record of 22 Grand Slam singles titles with the win.
Nine-time champion Djokovic will meet third seed Stefanos Tsitsipas in Sunday's decider after the Greek booked his first final at Melbourne Park by beating Russian Karen Khachanov.
Khachanov reached the semifinals after ailing American Sebastian Korda retired while trailing 7-6(5), 6-3, 3-0.
A year after dumping Sinner out in the quarters at Melbourne Park, third seed Tsitsipas crushed the Italian's hopes of a great escape.
Tsitsipas will next take on Italian Jannik Sinner in what could be a tricky test.