Evacuation orders were issued for some areas in the Philippines and southwestern Japanese coasts because of warnings of tsunami waves of a metre (3 feet) or more.
Epicentre for the quake was 233 kilometres north of Ayodhya in Uttar Pradesh.
Prime Minister Pushpa Kamal Dahal expressed deep sorrow at the loss of life and property in the quake.
According to the National Center for Seismology, the epicentre of the quake is Nepal.
An earthquake shook the country on September 8.
Neighbours Pakistan and Iran have offered to send rescue workers and humanitarian aid, while China's Red Cross Society offered cash relief aid.
Partners and local authorities anticipate the number of casualties to increase as search and rescue efforts continue amid reports that some people may be trapped under collapsed buildings
There was no immediate report of loss of life or property in the mountainous region.
The army said it was reinforcing search-and-rescue teams, providing drinking water, and distributing food, tents and blankets.
Many people were spending a third night in the open after the 6.8 magnitude quake hit late on Friday.