Ferland Mendy grabbed a late winner to earn lacklustre Real Madrid a 1-0 win over 10-man Atalanta.
Eden Hazard scored his first goal in almost three months while Karim Benzema bagged a brace as Real Madrid eased to a 4-1 win away to Alaves.
Raul Garcia scored twice in a 2-1 win over Real Madrid on Thursday to knock the holders out of the Spanish Super Cup and set up a final against Barcelona.
The victory took Atletico on to 41 points after 16 games, four clear of second-placed Real Madrid who have played 18.
Lionel Messi and Antoine Griezmann each scored twice as Barcelona thrashed Granada 4-0 away to win a third consecutive La Liga game for the first time this season.
The win took the Spanish champions to the summit on 36 points, one ahead of second-placed Atletico who have three games in hand.
A Luis Suarez header gave Atletico Madrid a 1-0 home win over Getafe in coach Diego Simeone's 500th game in charge.
A towering header from Casemiro and an added-time strike from Karim Benzema saw Real Madrid beat a stubborn Granada side 2-0 at home.
The Catalans have endured an inconsistent season so far, losing four times already in the league.
Atletico still lead the standings on 26 points, while Real climbed to third and closed the gap on their city rivals to three points, although Diego Simeone's side has a game in hand.