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Anderson (5/56) completed his 29th five-for in Tests to wrap up the Pakistan innings. Play was stopped due to bad light before Pakistan could bat again, with the visitors trailing by 310 runs.
Pakistan, who followed on after being bowled out for 273 in reply to England's first innings 583/8 declared, ended the penultimate day on 100/2, still requiring 210 runs to make England bat again.
Pakistan opener Abid Ali scored a half-century but England's seam bowlers used the muggy conditions to their advantage to restrict the tourists to 126/5.
The hosts completed the job with openers Tom Latham (52) and Tom Blundell (55) doing the bulk of the scoring.
The series loss underlines the fact that Virat Kohli and Co. remain a very beatable side in SENA countries.
According to Miandad, Kohli has performed across the world and his stats speak for himself.
At stumps, Rishabh Pant (1) and Hanuma Vihari (5) were at the crease with India leading by 97 runs with four wickets in hand.
Jadeja took a sensational one-handed airborne catch at deep mid-wicket to end Wagner's fighting knock at the stroke of tea.
Playing in his 58th Test, Karunaratne was 46 not out when a bouncer by Pat Cummins glanced off his shoulder and onto his helmet, close to the neck area.
England wrapped up a comprehensive 232-run victory over the West Indies in the third Test in St Lucia.
Results 1111-1120 of 1211
