Rohit Sharma has been rendered doubtful for the Edgbaston Test against England after testing positive for COVID-19.
Shikhar Dhawan and Bhanuka Rajapaksa scored 43 each up the order, while M Shahrukh Khan and Odean Smith remained not out on 24 and 25 respectively.
Seven members, including four players -- Shreyas Iyer, Shikhar Dhawan, Ruturaj Gaikwad and Navdeep Saini -- have tested positive for COVID-19 ahead of the series against the West Indies.
India lost Wrridhiman Saha (27) and Ravichandran Ashwin off successive balls early in the session before Mayank Agarwal (146 batting) and Axar Patel (32 batting) shared an unbeaten 61-run stand.
K L Rahul could partner Rohit Sharma at the top of the order in the first Test which begins on Wednesday.
Rahul has flown to Mumbai for surgery and further treatment.
The in-form Mayank Agarwal is likely to open with Shikhar Dhawan in Rohit's absence in the ODI series beginning Friday.
Opener Ruturaj Gaikwad scored his third successive fifty as CSK overhauled the target of 154 in 18.5 overs to dash Kings XI's hopes.
The save proved crucial for his side as Kings XI needed only 12 to win when the target could easily have been 16.
Skipper Virat Kohli confirmed that K L Rahul will continue to bat in the middle order.