The Malaysian Open, which runs from May 25-30, is one of the final two events where Olympic hopefuls can collect points towards the Race to Tokyo rankings.
Carolina Marin and world No. 1 Kento Momota will be the top seeds in the Super 500 event to be held in New Delhi from May 11 to 16.
The former national coach added it will be very tough for Saina Nehwal to make it to Tokyo given her recent results.
Sindhu, the Olympic silver medallist, couldn't match the pace, power and precision of her younger world No. 11 rival Chochowong and lost 17-21, 9-21 in a match that lasted 43 minutes.
Lakshya Sen crashed out after losing to Mark Caljouw of the Netherlands 17-21, 21-16, 17-21 in the quarterfinals.
H S Prannoy lost 15-21, 14-21 to Japanese world No. 1 Kento Momota.
The Indian women's duo of Ashwini Ponnappa and N Sikki Reddy and men's doubles pair of Satwiksairaj Rankireddy and Chirag Shetty progressed to the second round with straight game wins.
The Chinese, Koreans and Chinese Taipei shuttler have decided not to compete in the Super 1000 event as it is not part of the Tokyo Olympic qualification period, while the injured Carolina Marin has opted out.
The Spanish shuttler won 21-12, 21-5 in a lopsided match.
Former champion Kidambi Srikanth, however, couldn't cross the semifinal stage as he went down 13-21, 19-21 to top seed and former world champion Viktor Axelsen.