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The win helped Mumbai consolidate their top spot with 20 points from three matches. Kerala remain on four points from three games.
Veteran Saxena has the highest base price (Rs 40 lakh) among Kerala players.
Though Maharashtra began their daunting chase of 384 spiritedly, they lost their way once the 139-run opening stand between Kaushal S Tambe and Om Bhosale was broken.
Kerala have made it five wins in a row in the T20 tournament.
Hanuma Vihari will lead the 15-member squad.
Rohan aggregated 311 runs at an average of 62.20 as South Zone emerged champions in the Deodhar Trophy last week.
The Kerala opener scored a century to help South Zone to 328/8. East Zone lost by 45 runs.
Rohan's 58-ball knock was studded with eight fours and five sixes as South Zone overhauled the modest target of 137 in just 19.3 overs.
Mayank Agarwal has been named the captain while Rohan will be his deputy.
A & S Cricket Academy, Kolkata, emerged winners by 122 runs.