The surgery, named high tibial osteotomy, is a knee surgery aimed at younger patients in the earlier stages of knee osteoarthritis.
The study shows that methotrexate can be an effective intervention for people with knee OA who experience pain and inflammation.
Researchers from Brown University analysed a decade of prescription and insurance information from a large US national database.
Corticosteroid injections are often given to reduce pain and inflammation from osteoarthritis.
Hereditary causes have also been attributed to the condition of rubbing thighs and knees.
Dr Thomas Coon, a US-based expert says that orthopaedic surgeries have come of age globally with the fast adoption of robot-assisted surgeries.