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The Padma Shri recipient, was the founding director of Regional Cancer Centre, was 81.
She was battling for life at the Thiruvananthapuram Government Medical College hospital for the last one month after she met with the accident on May 15 and breathed her last early this morning.
Nine-year-old Shivakiran is undergoing treatment for blood cancer.
The RCC, located in the state capital, is the premier cancer care facility in Kerala and already numerous Maldives nationals have arrived here for cancer treatment.