KCA XI crushed DDCA XI by 129 runs.
Abdul Bazith, Salman Nizar, Krishna Prasad and Mohammed Azharuddeen scored fifties for Kerala.
Ten Kerala players are in the fray.
Azhar's 47-ball unbeaten 95 contained eight fours and six sixes.
Azharuddeen was named both player of the final and player of the series.
Athreya CC scored a narrow 10-run win over BK 55 CC in another match.
Padikkal, who has tested positive for COVID-19, is likely to miss RCB's first few matches and as a result Azhar could open the innings along with Kohli.
Both Karnataka and Kerala have 12 points from four matches. Kerala take on Bihar in their final Elite Group C match on Sunday.
The wicketkeeper-batsman was bought by RCB for his base price of Rs 20 lakh.
Kerala's outstation professional Jalaj Saxena was picked up by Punjab Kings for his base price of Rs 30 lakh.