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Madhwal, an engineer from Uttarakhand, returned sensational figures of 5/5 in 3.3 overs as MI inched one step closer to the IPL summit clash.
LSG omitted attacking wicketkeeper-opener Quinton de Kock from their playing XI and it turned out to be a big blunder.
This was MI's maiden win over LSG in four matches. MI will take on defending champions Gujarat Titans in the second Qualifier on Friday.
MI sealed their place in the playoffs after Royal Challengers Bangalore went down to Gujarat Titans in the final league match.
Asked to bat first, Marcus Stoinis hit a whirlwind 89 off 47 balls to power Lucknow Super Giants to a challenging 177 for 3.
Vishnu, who came in to bat at No. 5, put on 65 runs along with Suryakumar Yadav off 42 balls in a rollicking stand.
GT ended up with 191/8 in their chase of 219, thanks largely to Rashid Khan's unbeaten 79 off 32 balls.
As per a report in Daily Mail, Archer is set to be offered a year-round, multi-million-pound deal by the five-time IPL winning team that would require the ECB to gain permission from the IPL franchise to pick him for England's international matches.
Chasing 200, MI maintained their impeccable record of not losing to RCB at the Wankhede Stadium since IPL 2015, racing to victory in 16.3 overs.
Vishnu held on to the catch off Cameron Green's bowling in his third attempt much to the relief of MI captain Rohit Sharma.
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