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Anderson claimed three wickets with the new ball as Pakistan crumbled to 24/3 in reply to England's first innings total of 583/8 declared at close on day two.
Only 134.3 overs were possible in the entire match, which included a 38-over spell late on the fifth afternoon as the sun finally came out.
England were teetering at 92/4, 234 runs behind Pakistan’s competitive first innings total of 326, at close on day two.
The England fast bowler has been fined 15 per cent of his match earnings by match referee Chris Broad for using "inappropriate language" after dismissing Pakistan spinner Yasir Shah in the first Test at Manchester.
Pakistan closed a rain-shorted opening day of the first Test against England on 139/2 at a gloomy and wet Old Trafford.
Anderson reached the 600-wicket milestone as the rain-affected third Test ended in a tame draw. England won the series 1-0.
It had been an agonising wait for Anderson, marooned on 599 wickets after his teammates dropped four catches in 37 balls off his bowling in the innings.
Pakistan closed the third day on 137/8 in their second innings, an overall lead of 244 on a wearing wicket where the tourists’ spinners bowled England out for 219.
Akhtar said that it was the first time he had done so on purpose and he apologised to the former Indian captain after that.
Buttler and Woakes launched a superb counter-attack to turn the tide of the match towards the hosts with a sixth-wicket stand worth 139 runs.
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