Krishna and Vishnu lost to England's Ben Lane and Sean Vendy 21-19, 14-21, 19-21 in a 56-minute battle.
Ashwini Ponnappa lost in both the women's' doubles and mixed doubles semifinals partnering Sikki Reddy and Dhruv Kapila respectively.
Former world No. 1 Srikanth cut a sorry figure as he went down 19-21, 17-21 to France's Toma Junior Popov in a men's singles quarterfinal.
Sindhu, the Olympic silver medallist, couldn't match the pace, power and precision of her younger world No. 11 rival Chochowong and lost 17-21, 9-21 in a match that lasted 43 minutes.
Lakshya Sen crashed out after losing to Mark Caljouw of the Netherlands 17-21, 21-16, 17-21 in the quarterfinals.
H S Prannoy lost 15-21, 14-21 to Japanese world No. 1 Kento Momota.
The Indian women's duo of Ashwini Ponnappa and N Sikki Reddy and men's doubles pair of Satwiksairaj Rankireddy and Chirag Shetty progressed to the second round with straight game wins.
The testing process was something that left a few players puzzled with 2012 London Olympics bronze medallist Saina Nehwal and her husband Parupalli Kashyap both tweeting their frustration.
The Chinese, Koreans and Chinese Taipei shuttler have decided not to compete in the Super 1000 event as it is not part of the Tokyo Olympic qualification period, while the injured Carolina Marin has opted out.
The Spanish shuttler won 21-12, 21-5 in a lopsided match.